8:00 am
Registration & Morning Networking Coffee
9:00 am Panel Discussion: Leveraging Disease Pathology & Pathways Understanding to Fast-Track Innovations of Next Generation Animal Vaccines with Better Efficacy & Applicability
Synopsis
- Where could innovation come from in the next few years to tribalize the field of animal vaccine development?
- What have we learned so far from emerging disease pathways and pathology to help develop better vaccines in the future?
- How to better understand disease inducing pathways in animals to identify novel druggable targets with improved therapeutic efficacy?
- What are the main challenges and bottlenecks to overcome to fast-track next generation vaccine R&D?
9:45 am Using NGS as a Tool for Vaccine Strain Selection
Synopsis
- How to discern commensals from clinical agents?
- What types of NGS characterization are being successfully used at Vaxxinova?
10:15 am
Morning Break and Speed Networking
Optimizing Novel Vaccine Technologies to Increase Vaccine Safety & Efficacy
11:00 am Development & Applications of the RNA Particle Vaccine Platform for Animal Health
Synopsis
- Development and commercialization of the first USDA-approved production platform vaccine technology
- Comparison to other RNA and DNA vaccine platforms
- Current and future uses of the technology in livestock and companion animals
11:30 am Analysing Development & Manufacturing of DNA Vaccines
Synopsis
- What can the DNA plasmids add to the current veterinary vaccine portfolio?
- Considerations in scaling-up of DNA plasmids manufacturing process
- Solving the big hurdle: Exploring the current efforts intended to overcome the delivery issue
12:00 pm Development of Next Generation RNA Vaccines for Veterinary Pathogens
Synopsis
- Synthetic RNA vaccines and rapid response capability to emerging/re-emerging pathogens
- Use of self-amplifying RNA approach to mRNA vaccine development
- Increased safety and reduced vaccine dose benefits of self-amplifying RNAs
12:30 pm
Networking Lunch Break
Unleashing Next Generation Animal Vaccines to Advance Treatments Beyond Infectious Diseases
1:30 pm Therapeutic VLP Based Vaccines for the Treatment of Chronic Pain in Animals
Synopsis
- VLP platforms used for the development of therapeutic vaccines to treat chronic pain
- Proof of principle study for the treatment of pain by therapeutic vaccination in osteoarthritic mice
- Therapeutic vaccination for the treatment of chronic pain in companion animals
2:00 pm Utilizing Next Generation Animal Vaccine Technologies to Fight Cancer
Synopsis
- What are the key challenges and considerations for next generation cancer vaccines for animals to supercharge the pipelines?
- How are combination therapeutic strategies critical to enhancing the success rates of cancer vaccines?
- What technological advances are on the horizon that may improve cancer treatment success rates?
2:30 pm Roundtable Discussion: From Concept to Real World Applications: How to Expand Next Generation Animal Vaccine Utility to Combat Non-Infectious Diseases in Cancer, Chronic Pain, Allergies & Beyond
Synopsis
- How to justify and improve cost versus commercial gain to continue investment into non-infectious disease vaccine development for animals?
- How to better optimize target identification and validation strategies to produce preventative vaccines for non-infectious diseases?
- From an unmet needs perspective, what diseases should we prioritize next?
- How to leverage learning from human cancer research to identify targets to produce prophylactic vaccines for animals?
3:15 pm
Afternoon Networking Break
Developing Livestock Vaccines 2.0 to Combat Emergent Viral Strains and ensure a Sustainable Production Line
3:45 pm Computationally Optimized Broadly Reactive Antigens (COBRA) as Next Generation Broad Spectrum Vaccine Against Bird Flu
Synopsis
- Generation of broadly reactive antigens, to overcome diversity of pathogens
- Mass application of synthetic antigens using viral vectors
- Multivalent vaccine application: combating multiple diseases with one vaccine
4:15 pm Rational Development of Live Attenuated African Swine Fever Vaccines
Synopsis
- Discovery of African Swine Fever virulent factors
- Production of attenuated strains of African Swine Fever
- Development of safety and efficacious African Swine Fever live attenuated vaccines
4:45 pm Highly Athogenic Avian Influenza Viruses (HPAIV) in Egypt & Factors Related to Failure Eradication Strategies
Synopsis
- HPAI H5 could become endemic or be eradicated through monitoring, biosecurity, and depopulation
- Leveraging genetic shifts observed in long-term circulating viruses; H5N8 clade reported in 2016
- Analyzing H5 vaccine evaluation and challenges with antigenic variants
- Discussing the importance of emphasis on high-quality vaccines and proper administration for effective immunity